The overall humanitarian response in Mozambique is led and coordinated by the national authorities through the National Institute of Disaster Management (INGC) and related emergency coordination mechanisms. This is supported by the Humanitarian Country Team (HCT), which is composed of UN agencies, International and National NGOs, Red Cross and donor representatives. The HCT is supported at the operational level by an Inter-Cluster Coordination Group (ICCG). Specifically, the COVID-19 public health response is led by the Minsterio da Saude (MISAU), supported by WHO and partners, through a Health Partners Group. A national COVID-19 Preparedness and Response Plan was developed around 10 pillars: Coordination, Surveillance, Laboratory, Case management, IPC and WASH, Advocacy communication and community involvement, medicines and supplies, Operational support and logistics). A Technical Advisory Team (TAT) composed of experts from WHO, UNICEF, Centers for Disease Control and Prevention (CDC), World Bank, USAID, UNFPA was established with the overall objective to coordinate, add quality and harmonize outputs from the various TWGs. All of these teams are active and continue to function while a similar structure is being implemented through the DPS and Governors offices at provincial level. Prevention of sexual exploitation and abuse (PSEA) will be a central tenet of the response. The PSEA Network will serve as the primary body for coordination and oversight of activities related to protection from sexual exploitation and abuse by international and national personnel of UN, NGO entities and associated personnel involved in the response. The PSEA Network will provide technical support to the clusters, agencies and partners to ensure capacity building and community awareness on PSEA, access to safe reporting mechanisms and referral of SEA survivors to assistance services.